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Raised, rolled, reddened, or darkened wound edges might reflect delayed healing or pathological changes, while dryness, flaking, redness, tension, shininess, or pigmentation changes in adjacent skin can signal abnormal tissue responses [27]

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The cholinergic system plays crucial roles in regulating memory, learning, stress, rapid-eye-movement (REM) sleep, attention, and other cognitive functions [84,87]

However, testing using a diurnal animal model would be required to confirm this